Familiar hypertrophic cardiomyopathy type II

Type II familial hypertrophic heart disease is an inherited coronary artery disease characterized by a thickening of the heart muscle, which typically occurs in the wall that separates the left and right ventricle (interventricular septum). The difference with type I is morphological since type II affects the entire interventricular septum and not only the anterior part. This thickening is called left ventricular hypertrophy (LVH). The clinical manifestations of this disease range from asymptomatic LVH to sudden cardiac death, including arrhythmias or atrial fibrillation, and it develops mainly during adolescence or adulthood. However, it can also occur in childhood and senescence. Studies show that mutations in the TNNT2 gene correlate with an increased predisposition to type I familial hypertrophic heart disease.